(12) PATENT APPLICATION PUBLICATION (21) Application No. : 1274/MUM/2005 (19) INDIA (22) Date of filing of Application :10/10/2005 (43) Publication Date : 29/06/2007        Journal No. - 26/2007   (54) Title of the invention : NOVEL CRYSTALLINE POLYMORPHIC FORM OF A CAMPTOTHECIN ANALOUGE   (51) International classification :A61K31/4745 (31) Priority Document No :NA (32) Priority Date :NA (33) Name of priority country :NA (86) International Application No         Filing Date :NA :NA (87) International Publication No :NA (61) Patent of Addition to Application Number         Filing Date :NA :NA (62) Divisional to Application Number         Filing Date :NA :NA   (71)Name of Applicant :    1)CIPLA LIMITED       Address of Applicant :289, BEELLASIS ROAD,MUMBAI CENTRAL, MUMBAI 400 008 Maharashtra India (72)Name of Inventor :    1)PATHI SRINIVAS LAXMINARAYAN (India)    2)KANATHALA, SHASHI REKHA (India)    3)GANGRADE, MANISH GOPALDAS (India)    4)KANKAN, RAJENDRA NARAYANRAO (India)    5)RAO DHARAMARAJ RAMACHANDRA (India) (57) Abstract : Disclosed herein is a novel crystalline polymorphic Form-A of Topotecan hydrochloride which is characterized by an XRD pattern having peak positions at 6.08, 6.94, 8.10, 9.96, 10.16, 11.68, 12.28, 13.08, 13.62, 14.32, 15.44, 16.46, 16.56, 17.58, 18.42, 19.32; 20.14, 21.22, 22.54, 22.72, 23.38, 24.14, 24.36, 24.78, 25.02, 25.50, 26.42, 26.86, 27.18, 27.44, 28.10, 28.76, 29.42, 29.68 and 30.02. The invention also discloses processes for preparation of Topotecan hydrochloride form A.   Number of Pages = 13