(12) PATENT APPLICATION PUBLICATION (21) Application No. : 972/BOM/1999 (19) INDIA (22) Date of filing of Application :28/12/1999 (43) Publication Date : 04/03/2005        Journal No. - 111   (54) Title of the invention : NEW POLYMORPHIC FROM OF OLANZAPINE   (51) International classification :C07D243/26 A61K31/55 (31) Priority Document No :NA (32) Priority Date :NA (33) Name of priority country :NA (86) International Application No         Filing Date :NA :NA (87) International Publication No : NA (61) Patent of Addition to Application Number         Filing Date :NA :NA (62) Divisional to Application Number         Filing Date :NA :NA   (71)Name of Applicant :    1)CIPLA LIMITED       Address of Applicant :289, BELLASIS ROAD, MUMBAI CENTAL, MUMBAI 400008 Maharashtra India (72)Name of Inventor :    1)RAJENDRA NARAYANRAO (India)    2)DHARAMRAJ RAMCHANDRA RAO (India) (57) Abstract : Invention provides three new polymorphic from of Olanzapine for treatment of psychotic conditions. The new polymorphic forms of Olanzapine are designated as form III form IV and form V, which are conveniently prepared by dissolving Olanzapine in an aqueous organic or inorganic acid and precipitated using a suitable base. The Olanzapine can be obtained by varying the concentration of the acid, the temperature of precipitation and pH of the resultant mass after neutralization with alkali.   Number of Pages = 21